Natalia Quinones‐Olvera

Complete genomes from 151 clinical M. tuberculosis isolates show gene conversion between paralogs creating diversity hotspots in PE/PPE/ESX genes and T cell antigens, including PPE18.

TIGRFinder annotated 6,685 TIGR arrays; cryo-EM structures show inactive RuvC domains, and E. coli reporter assays show CsTasR and MbTasA repress transcription in a guide-dependent manner.

Phage DisCo identifies phages that interact with specific bacterial traits by co-culturing strains with fluorescent tags and perturbations, using plaque morphology to detect infection inhibition.

The paper evaluates pan-genome analysis methods using M. tuberculosis isolates, finding that annotation discrepancies and assembly quality affect results, and introduces panqc to address these issues.

This paper introduces phylogenetic compression to efficiently search large microbial genome collections, achieving significant compression improvements and enabling fast BLAST-like searches on desktop computers.

The paper demonstrates that RNA-guided nuclease TnpB enables gene drive in plasmids by biasing the inheritance of insertion sequences.