Scouring the human Hsp70 network uncovers diverse chaperone safeguards buffering TDP-43 toxicity
Edward M. Barbieri, Miriam Linsenmeier, Katherine R. Whiteman, Yan Cheng, Sylvanne Braganza, Katie E. Copley, Paola Miranda-Castrodad, Brennen Lewis, Kevin Villafañe, Defne A. Amado, Beverly L. Davidson, James Shorter
The paper identifies chaperones in the human Hsp70 network that buffer TDP-43 toxicity by reducing aggregates and enhancing solubility.
bioRxiv · May 10, 2025 · PreprintBiochemistry