Paola Miranda-Castrodad

Genetic Code Expansion, Enzymatic Modification, and C-Terminal Labeling Enable Facile Production of Highly Modified α-Synuclein

This study develops a method to produce highly modified α-synuclein with defined post-translational modifications and a fluorescent label to study their effects on structure and function.

Scouring the human Hsp70 network uncovers diverse chaperone safeguards buffering TDP-43 toxicity

The paper identifies chaperones in the human Hsp70 network that buffer TDP-43 toxicity by reducing aggregates and enhancing solubility.