Miriam Linsenmeier

Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration

Short UG-rich RNAs bind and stabilize TDP-43 RNA-recognition motifs to allosterically destabilize its prion-like domain helical region, preventing aggregation and mitigating neurodegeneration in cells and mice.

Nuclear-import receptors remodel the dilute phase to suppress phase transitions of RNA-binding proteins with prion-like domains.

This study shows nuclear-import receptors suppress RNA-binding protein phase transitions by remodeling the dilute phase, preventing disease-linked aggregation.

Scouring the human Hsp70 network uncovers diverse chaperone safeguards buffering TDP-43 toxicity

The paper identifies chaperones in the human Hsp70 network that buffer TDP-43 toxicity by reducing aggregates and enhancing solubility.