Role Of Chymotrypsin-Like Elastase 1 In Lung Physiology And in α1-Antitrypsin Deficiency
Rashika Joshi, Andrea Heinz, Qiang Fan, Shuling Guo, Brett Monia, Christian E.H. Schmelzer, Anthony S. Weiss, Matthew Batie, Harikrishnan Parameswaran, Brian M. Varisco
This study shows Cela1 is responsible for stretch-inducible lung elastase activity and is required for emphysema in AAT deficiency, with conserved features in placental mammals.
bioRxiv · May 16, 2017 · PreprintPhysiology