Author

Rashika Joshi

Cincinnati Children's Hospital Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 1 Pathology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Brian Michael VariscoiD· 2 shared Noah J. SmithiD· 2 shared Qiang Fan· 2 shared Andrea D. EdwardsiD· 1 shared Andrea Heinz· 1 shared Andrew J. Devine· 1 shared Ansley N. Varisco· 1 shared Anthony S. Weiss· 1 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersPathology

Brian Michael VariscoORCID

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Author profile →

3 papers

Recent·Most cited

KF4 anti-CELA1 Antibody and Purified α1-Antitrypsin Have Similar but Not Additive Efficacy in Preventing Emphysema in Murine α1-Antitrypsin Deficiency

Andrew J. Devine, Noah J. Smith, Rashika Joshi, Brandon Brooks-Patton, Jenna Dunham, Ansley N. Varisco, Emily M. Goodman, Qiang Fan, Basilia Zingarelli, Brian M. Varisco

This study evaluates KF4 anti-CELA1 antibody and purified α1-antitrypsin in preventing emphysema in AAT-deficient mice, finding similar efficacy with no additive benefit when combined.

Chronic Obstructive Pulmonary Diseases Journal of the COPD Foundation · Nov 26, 2024Peer-reviewedPathology

Inhibition of CELA1 Improves Septation in the Mouse Hyperoxia Model of Impaired Alveolar Development

Noah J. Smith, Rashika Joshi, Hitesh Desmukh, Jerilyn K. Gray, Andrea D. Edwards, Elham Shahreki, Brian Michael Varisco

bioRxiv · Jun 13, 2024 · PreprintDevelopmental Biology

Role Of Chymotrypsin-Like Elastase 1 In Lung Physiology And in α1-Antitrypsin Deficiency

Rashika Joshi, Andrea Heinz, Qiang Fan, Shuling Guo, Brett Monia, Christian E.H. Schmelzer, Anthony S. Weiss, Matthew Batie, Harikrishnan Parameswaran, Brian M. Varisco

This study shows Cela1 is responsible for stretch-inducible lung elastase activity and is required for emphysema in AAT deficiency, with conserved features in placental mammals.

bioRxiv · May 16, 2017 · PreprintPhysiology