Brian Charlesworth

The effect of a reduction in population size on mean fitness and inbreeding depression

The paper develops a theoretical framework to predict how population bottlenecks affect mean fitness and inbreeding depression, showing that recovery depends on selection strength and mutation recessivity.

Maintenance of quantitative genetic variation in regions of restricted recombination via associative overdominance

The paper shows that weakly selected QTLs linked to regions with associative overdominance can increase additive genetic variance, but recessive deleterious alleles may reduce fitness when exposed by selection.

A gene-based model of fitness and its implications for genetic variation: Genetic and inbreeding loads

The paper compares the gene model and sites model of fitness, showing the gene model leads to lower genetic load and smaller inbreeding load, suggesting overestimation of inbreeding depression.

A gene-based model of fitness and its implications for genetic variation: Linkage disequilibrium

The paper compares two models of mutation effects on fitness, showing the gene model predicts positive linkage disequilibrium where the sites model predicts zero or negative LD.

Beyond Recombination: Exploring the Impact of Meiotic Frequency on Genome-wide Genetic Diversity

This study examines how meiotic frequency and sexual strategies affect genetic diversity in facultatively sexual species like yeast, showing that low meiotic frequency can reduce genome-wide diversity during selective sweeps.

A model of Hill-Robertson interference caused by purifying selection in a non-recombining genome

The paper develops a model to analyze Hill-Robertson interference in non-recombining genomes, showing accurate approximations for mutation frequencies and genetic diversity.

The fitness consequences of genetic divergence between polymorphic gene arrangements

This paper investigates the fitness consequences of genetic divergence between polymorphic gene arrangements using analytical and numerical methods, finding that heterokaryotypes have a selective advantage when arrangements are nearly equal in frequency.

The effects of inversion polymorphisms on patterns of neutral genetic diversity

This paper extends theoretical models of inversion polymorphisms to a finite island model, analyzing their effects on genetic diversity and linkage disequilibrium in Drosophila melanogaster.

Evidence for a force favouring GC over AT at short intronic sites in Drosophila simulans and D. melanogaster

The paper investigates GC-biased gene conversion in Drosophila species using short intronic sites, finding a weak GC-favoring force stronger in D. simulans than D. melanogaster.