A Human Neuronal Co-Culture System Reveals Early Tumor-Neuron Communication and Targetable Pathways in Glioblastoma
Ouada Nebie, Niyi Adelakun, Liwen Zhang, Luke Kollin, Brian D. Fries, Akhil Medikonda, Monica Venere, Pierre Giglio, Nam Ky Chu, Nhat T. T. Le
This paper develops a human neuronal co-culture system to study early glioblastoma-neuron interactions, revealing source-specific synaptic remodeling and targetable MAPK pathway vulnerabilities.
bioRxiv · Sep 10, 2025 · PreprintCancer Biology