Nhat T. T. Le

The paper identifies prion synaptotoxic pathways and inhibitory drugs using phosphoproteomic and transcriptomic data from prion-treated neurons.

This paper identifies elacridar as a compound that prevents prion infection by enhancing lysosomal function, showing effects against PrPSc, α-synuclein, and tau prions.

This paper develops a human neuronal co-culture system to study early glioblastoma-neuron interactions, revealing source-specific synaptic remodeling and targetable MAPK pathway vulnerabilities.

This study uses iPSC-derived neurons from a family with the E200K prion mutation to model disease-relevant phenotypes, including PrP accumulations and NMDA receptor misalignment.

The paper identifies sigma receptor ligands as potent anti-prion compounds that are effective regardless of sigma receptor binding.