Pierre Giglio

This study identifies the BNIP3-mTOR signaling axis as a mediator of resistance to MET inhibition in glioblastoma and shows that combined MET and mTOR inhibition synergistically enhances anti-tumor effects.

This paper develops a human neuronal co-culture system to study early glioblastoma-neuron interactions, revealing source-specific synaptic remodeling and targetable MAPK pathway vulnerabilities.