Operant alcohol self-administration targets GluA2-containing AMPAR expression and synaptic activity in the nucleus accumbens in a manner that drives the reinforcing properties of the drug
Sara Faccidomo, Briana L. Saunders, Ashley M. May, Vallari R. Eastman, Michelle Kim, Seth M. Taylor, Jessica L. Hoffman, Zoé A. McElligott, Clyde W. Hodge
This study shows that ethanol self-administration increases GluA2-containing AMPAR expression and synaptic activity in the nucleus accumbens, which enhances ethanol's reinforcing effects through an NSF-dependent mechanism.
bioRxiv · Sep 13, 2024 · PreprintNeuroscience