Seth M. Taylor

TARP γ-8 is a target of ethanol that regulates self-administration and relapse in mice

This study shows that TARP γ-8 regulates ethanol reinforcement and relapse in mice, with reduced self-administration and cue-induced reinstatement in TARP γ-8 heterozygous null mice.

Sex Differences in Home-Cage Ethanol Drinking and Operant Self-Administration in C57BL/6J Mice but Equivalent Regulation by Glutamate AMPAR Activity

This study examines sex differences in ethanol consumption and its regulation by glutamate AMPA receptors in C57BL/6J mice, finding higher ethanol intake and reinforcement in females.

Developmental and conditional regulation of DAF-2/INSR ubiquitination in Caenorhabditis elegans

The paper shows that DAF-2/INSR ubiquitination by CHN-1/CHIP regulates IIS differently in larvae and adults, and under varying temperature and nutrient conditions.

Operant alcohol self-administration targets GluA2-containing AMPAR expression and synaptic activity in the nucleus accumbens in a manner that drives the reinforcing properties of the drug

This study shows that ethanol self-administration increases GluA2-containing AMPAR expression and synaptic activity in the nucleus accumbens, which enhances ethanol's reinforcing effects through an NSF-dependent mechanism.

Inhibition of AMPA receptors bound to transmembrane AMPA receptor regulatory protein γ-8 (TARP γ-8) blunts the positive reinforcing properties of alcohol and sucrose in a brain region-dependent manner

This study inhibits TARP γ-8 bound AMPARs in specific brain regions to show their role in alcohol and sucrose reinforcement, finding region-specific effects on reward behavior.

Alternative somatic and germline gene-regulatory strategies during starvation-induced developmental arrest

The paper shows that during starvation, somatic cells rely on active transcription for survival while germline cells use transcriptional quiescence and mRNA stability to preserve reproductive potential in C. elegans.

Calcium-Permeable AMPA Receptor Activity and GluA1 Trafficking in the Basolateral Amygdala Regulate the Positive Reinforcing Effects of Alcohol

This study shows that calcium-permeable AMPA receptors and GluA1 trafficking in the basolateral amygdala regulate alcohol reinforcement in mice.

Alcohol Drinking Exacerbates Neural and Behavioral Pathology in the 3xTg-AD Mouse Model of Alzheimer’s Disease

This study shows that non-dependent alcohol drinking worsens AD-like neural and behavioral issues in 3xTg-AD mice.