Efficient in vivo mammalian neuron editing using peptide-mediated CRISPR enzyme delivery
Brigette D. Manohar, Meika Travis, Vikas Munjal, Christopher M. Baehr, Lily M. A. Rahnama, Min Hyung Kang, Rania F. Haddad, Kunica Asija, Eric A. Noel, Navya Peddireddy, Runvir S. Chouhan, Rohit Kumar Sharma, Stacia K. Wyman, Netravathi Krishnappa, Deirdre A. Killebrew, , Ross C. Wilson
This study develops Neuro-PERC, a peptide-mediated CRISPR delivery method, enabling efficient in vivo neuronal editing in mice and pigs, and extending survival in a Huntington's disease model.
bioRxiv · Nov 26, 2025 · PreprintNeuroscience