Ross C. Wilson

CRISPR-dPCR: A unified multiplex digital PCR framework for quantitative characterization of targeted knock-in

CRISPR-dPCR quantifies CRISPR knock-in by distinguishing integration from donor abundance and background, using multiplex digital PCR with orthogonal strategies.

Chemically modified CRISPR enzymes for multi-organ genome editing in vivo

This paper introduces PERCEPT, a CRISPR delivery platform that enables multi-organ genome editing in vivo by chemically modifying CRISPR enzymes for targeted and efficient delivery.

CRISPR-Mediated Targeting of BRAF Oncogenes in Pediatric Low-Grade Glioma

This study develops and validates CRISPR guide RNAs to target BRAF oncofusions and V600E mutations in pediatric low-grade glioma cells, achieving high indel frequencies and confirming junction excision.

Efficient in vivo mammalian neuron editing using peptide-mediated CRISPR enzyme delivery

This study develops Neuro-PERC, a peptide-mediated CRISPR delivery method, enabling efficient in vivo neuronal editing in mice and pigs, and extending survival in a Huntington's disease model.

Peptide-enabled ribonucleoprotein delivery for CRISPR engineering (PERC) in primary human immune cells and hematopoietic stem cells

This paper introduces PERC, a method for efficient CRISPR editing in primary human immune cells and HSPCs using a peptide reagent, achieving over 90% editing efficiency without specialized equipment.