Deciphering the role of the nanoscale clustering of activating and costimulatory antibodies on T cell activation
Guillaume Le Saux, Piotr Nowakowski, Esti Toledo, Sivan Tzdaka, Abed Alkader Yassin, Shagufta Naaz, Yuval Segal, Brit Maman, Angel Porgador, Ana‐Sunčana Smith, Mark Schvartzman
The paper investigates how nanoscale clustering and density of activating and costimulatory antibodies influence T cell activation, finding that global density is more critical than cluster size.
bioRxiv · Sep 28, 2024 · PreprintImmunology