Angel Porgador

This study develops a bispecific antibody that enhances T-cell engagement with AXL+ cells, improving anti-PD-1 therapy efficacy in HNSCC by remodeling the tumor microenvironment.

This study shows β-endorphin enhances NK cell cytotoxicity and EV-mediated anti-tumor activity by remodeling the cytotoxic secretome.

OptiRanker simulates and compares drug prioritization algorithms to rank their predictive accuracy, enabling efficient in vivo trial design for personalized medicine.

This study shows that T cells respond to mechanical heterogeneity by not averaging signals, leading to lower activation than on stiff surfaces, but long-term exposure enhances memory and effector T cell proliferation.

The paper investigates how nanoscale clustering and density of activating and costimulatory antibodies influence T cell activation, finding that global density is more critical than cluster size.