Guillaume Le Saux

This study shows that cells can be guided and tissues shaped by environmental stiffness heterogeneity alone, without topographical or chemical cues.

This study shows that T cells respond to mechanical heterogeneity by not averaging signals, leading to lower activation than on stiff surfaces, but long-term exposure enhances memory and effector T cell proliferation.

The paper investigates how nanoscale clustering and density of activating and costimulatory antibodies influence T cell activation, finding that global density is more critical than cluster size.