Identification of novel human cellular substrates of Staphylococcus aureus serine protease SplB
Christopher Saade, Hannes Wolfgramm, Manuela Gesell-Salazar, Christian Hentschker, Katrin Schoknecht, Jens Fielitz, Britta Fielitz, Ning Li, Leif Steil, Uwe Völker, Barbara M. Broeker, Alexander Reder, Kristin Surmann
This study identifies novel human substrates of Staphylococcus aureus protease SplB, revealing its cleavage of intermediate filaments and IgG, suggesting roles in immune evasion and tissue invasion.
bioRxiv · Sep 9, 2025 · PreprintImmunology