Uwe Völker

Gene-by-Sleep Duration Interaction for Glycemic Traits in over 480,000 Individuals

The paper identifies 16 genetic loci interacting with sleep duration to influence glycemic traits in over 480,000 individuals, revealing distinct biological mechanisms for short and long sleep.

Genomics of Educational Attainment Across 80 Years of Social and Political Transformation in Germany

The paper examines how polygenic indices for educational attainment change across birth cohorts and regions in Germany, finding stronger associations in recent cohorts and the East but weaker effects for women.

The Staphylococcus aureus serine protease-like protein B is a potent allergen in a murine asthma model

This study shows that S. aureus SplB induces asthma-like symptoms in mice, requiring proteolytic activity and adaptive immunity, suggesting a direct role of bacterial allergens in asthma.

Immunoglobulin sub-class levels define inter-donor plasma variability: a longitudinal dual-lab study

This study identifies immunoglobulin sub-class levels as key factors in inter-donor plasma variability using longitudinal proteomic data from two labs.

Epigenomic embedding of childhood adversity links to disease risk and chronic immune changes

The paper identifies contmeQTLs linking childhood adversity to epigenetic changes in immune cells, which are associated with disease risk and inflammatory profiles.

PneumoWiki: A pan-genome-based database for the pathogen Streptococcus pneumoniae

PneumoWiki is a pan-genome database for Streptococcus pneumoniae that integrates genomic data and functional annotations across 43 strains to support research and data analysis.

Genome-wide association study meta-analysis identifies susceptibility loci informing Ewing sarcoma etiology and potential mechanisms of risk

This study identifies 14 susceptibility loci for Ewing sarcoma through a genome-wide association meta-analysis, revealing genetic interactions with somatic EWSR1::FLI1 fusions.

Trans-eQTLs reveal the architecture of human gene regulatory networks

The paper maps cis- and trans-eQTLs in blood samples to infer gene regulatory networks and prioritize trait-relevant pathways.

Shared genetic architecture of brain age gap across 30 cohorts worldwide

This study identifies a shared genetic factor underlying brain age gaps across 30 cohorts, finding 19 SNPs and associations with health traits.

Detection of alternative splicing: deep sequencing or deep learning?

This study evaluates whether sequence-based tools can detect alternative splicing from low-depth RNA-seq data, showing promise for hypothesis generation but limitations in de novo detection.

Unraveling proteomic chaos by independent component analysis - ClpX proficiency promotes the iron and oxygen limitation responses of Staphylococcus aureus and affects the intracellular bacterial behavior

This study uses proteomics and independent component analysis to show ClpX regulates S. aureus responses to iron and oxygen limitation and affects bacterial fitness and virulence.

Requirement of ClpX for CtsR dissociation from its operator elements upon heat stress in Bacillus subtilis

This study shows that ClpX is required for CtsR dissociation from its operator elements during heat stress in Bacillus subtilis, highlighting its role in activating the stress response regulon.

Identification of novel human cellular substrates of Staphylococcus aureus serine protease SplB

This study identifies novel human substrates of Staphylococcus aureus protease SplB, revealing its cleavage of intermediate filaments and IgG, suggesting roles in immune evasion and tissue invasion.

Genomic and molecular evidence that the lncRNA DSP-AS1 modulates Desmoplakin expression

The paper identifies a variant in DSP associated with QRS interval and shows that DSP-AS1 regulates DSP expression through functional and Mendelian randomization analyses.

The global proteome of Streptococcus pneumoniae EF3030 under nutrient-defined in vitro conditions

This study optimizes a nutrient-defined medium for Streptococcus pneumoniae and uses it to analyze the global proteome during growth phase transitions, identifying proteins with altered abundance in late log phase.

Regulation of the transcriptome, miRNAs, and alternative splicing in a FSGS zebrafish injury model

This study investigates alternative splicing and miRNA regulation in a zebrafish FSGS model, identifying key splicing events and miRNAs associated with disease progression.

The Regulation of MAGI2 and its Diagnostic Application in Podocytopathies

This study identifies MAGI2 as a conserved biomarker for podocyte injury, showing its downregulation in glomerular diseases and differential expression in primary vs secondary FSGS.

Alternative splicing in mechanically stretched podocytes as a model of glomerular hypertension

The paper investigates alternative splicing in mechanically stretched podocytes, identifying splicing events in Shroom3 and Myl6 that may contribute to hypertensive nephropathy.

Temperature-dependent regulation of bacterial cell division hydrolases by the coordinated action of a regulatory RNA and the ClpXP protease

This study identifies a temperature-sensitive regulatory mechanism in Staphylococcus aureus involving an RNA and ClpXP protease that controls cell division hydrolases.

Lifestyle, Early-life, and Genetic Health Risk Factors Underlying the Brain Age Gap: A Mega-Analysis Across 3,934 Individuals from the ENIGMA MDD Consortium

This study identifies lifestyle, early-life, and genetic factors associated with brain age gaps in individuals with major depressive disorder compared to controls.

Integrated genomic and proteomic analysis of the mouse-adapted Staphylococcus aureus strain JSNZ

The paper characterizes a mouse-adapted Staphylococcus aureus strain JSNZ through genomic and proteomic analysis, identifying it as a valuable reference strain for infection research.

The tricellular junction protein ILDR2 in glomerulopathies: insights and implications

This study investigates ILDR2's role in glomerulopathies, finding it upregulated in disease models and suggesting a protective effect against glomerular damage.

RNA sequencing depth guidelines for the study of alternative splicing

The paper provides sequencing depth guidelines for comprehensive alternative splicing analysis across tissues, showing that current depths are insufficient and recommending deeper sequencing or long-read technologies.

Podocyte exopher-formation as a novel pathomechanism in membranous nephropathy

This study identifies podocyte exopher-formation as a novel mechanism for removing antigen/autoantibody aggregates in membranous nephropathy, with potential for non-invasive monitoring.

OTTERS: A powerful TWAS framework leveraging summary-level reference data

OTTERS is a TWAS framework that uses summary-level eQTL reference data to estimate eQTL weights and perform omnibus TWAS, showing improved power and applicability.

Predicting Peptide HLA-II Presentation Using Immunopeptidomics, Transcriptomics and Deep Multimodal Learning

The paper develops PIA-M, a multimodal transformer-based tool for predicting HLA-II peptide presentation, achieving higher accuracy and faster runtime than existing methods.

Alternative splicing analysis benchmark with DICAST

DICAST benchmarks alternative splicing analysis tools, showing STAR and HISAT2 perform best, and proposes a reporting standard for event detection.

Tissue-specific multiOMICs analysis of atrial fibrillation

This study integrates genomics, transcriptomics, and proteomics of human atrial tissue to identify regulatory variants and trans-acting networks associated with atrial fibrillation.

Differentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptome

This paper introduces revTWMR, a method to determine causal relationships between gene expression and complex traits, finding that traits more strongly influence gene expression than vice versa.

Unraveling the polygenic architecture of complex traits using blood eQTL meta-analysis

The paper uses blood eQTL meta-analysis to explore the polygenic architecture of complex traits, finding that trans-eQTLs are more informative for identifying causal genes than cis-eQTLs.