Target RNA-triggered CRISPR-Cas12a2 Preferentially Cleaves Collateral DNA over RNA
Sobita Kunwar, Thomson Hallmark, Sudeshna Manna, Dylan Keiser, Bronson Naegle, Aaron J. Thomas, Chase L. Beisel, Ryan N. Jackson
This study shows that Cas12a2 preferentially cleaves collateral DNA over RNA, revealing the mechanism and implications for CRISPR-based immunity and technology.
Nucleic Acids Research · May 28, 2026Peer-reviewedBiochemistry