Cancer BiologyCancer ResearchPeer-reviewed
Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma determine response to SLC7A11 inhibition
George Sharbeen, Joshua A McCarroll, Anouschka Akerman…·Phoebe A Phillips
This study shows that SLC7A11 in pancreatic ductal adenocarcinoma stroma, not tumor cells, predicts poor survival and that inhibiting it reduces CAF activity and tumor growth.
DOI 10.1158/0008-5472.can-20-2496