Bacterial Colonization Stimulates A Complex Physiological Response In The Immature Human Intestinal Epithelium
David R. Hill, Sha Huang, Melinda S. Nagy, Veda K. Yadagiri, Courtney Fields, Dishari Thornhill, Brooke Bons, Priya H. Dedhia, Alana M. Chin, Yu-Hwai Tsai, Shrikar Thodla, Thomas Mitchell Schmidt, Seth T. Walk, Vincent Bensan Young, Jason R. Spence
This study uses human intestinal organoids to show microbial colonization induces complex physiological changes in immature human epithelium, including antimicrobial peptide production and mucus maturation.
eLife · Nov 6, 2017Peer-reviewedDevelopmental Biology