Author

Bruce E. Hayward

National Institutes of Health

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 3 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Karen UsdiniD· 4 shared Carson J. MilleriD· 2 shared Daman KumariiD· 2 shared Alexandra WalkeriD· 1 shared André B. P. KuilenburgiD· 1 shared Cai McCanniD· 1 shared Clara van KarnebeekiD· 1 shared Diego Antonio JimeneziD· 1 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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4 shared papersGenetics

Karen UsdinORCID

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4 papers

Recent·Most cited

Reconciling the effects of PMS2 in different repeat expansion disease models supports a common expansion mechanism

Carson J. Miller, Diego Antonio Jimenez, Alexandra Walker, Kusala Anupindi, Bruce E. Hayward, Hernán Lorenzi, Karen Usdin, Xiao-Nan Zhao

The paper shows that PMS2 has similar effects in two different repeat expansion disease models, supporting a common expansion mechanism across Repeat Expansion Diseases.

PNAS Nexus · Jun 25, 2026Peer-reviewedGenetics

MSH2 is not required for either maintenance of DNA methylation or repeat contraction at the FMR1 locus in fragile X syndrome

Jessalyn Grant-Bier, Kathryn Ruppert, Bruce E. Hayward, Karen Usdin, Daman Kumari

This paper investigates the role of MSH2 in DNA methylation and repeat contraction at the FMR1 locus in fragile X syndrome and finds that MSH2 is not required for DNA methylation maintenance but is associated with MSH2-independent repeat contractions.

bioRxiv · Dec 20, 2024 · PreprintMolecular Biology

Repeat expansion in a Fragile X model is independent of double strand break repair mediated by Pol θ, Rad52, Rad54l or Rad54b

Bruce E. Hayward, Geum-Yi Kim, Carson J. Miller, Cai McCann, Megan G. Lowery, Richard Dean Wood, Karen Usdin

This study investigates the role of double-strand break repair proteins in repeat expansion in Fragile X disease models and finds that loss of Pol θ, Rad52, Rad54l, or Rad54b does not significantly affect expansion.

bioRxiv · Nov 5, 2024 · PreprintGenetics

All three MutL complexes are required for repeat expansion in a human stem cell model of CAG-repeat expansion mediated glutaminase deficiency.

Bruce E. Hayward, Daman Kumari, Saikat Santra, Clara van Karnebeek, André B. P. Kuilenburg, Karen Usdin

Scientific Reports · Jun 14, 2024Peer-reviewedGenetics