Richard Dean Wood

Repeat expansion in a Fragile X model is independent of double strand break repair mediated by Pol θ, Rad52, Rad54l or Rad54b

This study investigates the role of double-strand break repair proteins in repeat expansion in Fragile X disease models and finds that loss of Pol θ, Rad52, Rad54l, or Rad54b does not significantly affect expansion.

Mechanistic Basis for Microhomology Identification and Genome Scarring by Polymerase Theta

This study elucidates how DNA Polymerase Theta identifies microhomologies during repair and shows how this process leads to genomic scars in cancer.

FAM35A associates with REV7 and modulates DNA damage responses of normal and BRCA1-defective cells

This study identifies FAM35A as a REV7-associated protein that modulates DNA damage responses, showing altered expression in prostate cancer and resistance to PARP inhibitors in BRCA1-defective cells.