Full title Capsule and PspA Cooperatively Confer Resistance of Streptococcus pneumoniae to the Human defensin HNP-1
Thalita Bastos de Freitas Silva, Maria Eduarda Pereira Mendes, Rebeca Faria, Kelvin Gattinoni, Bruna Terribile, Giulia Destro, Lúcio Fábio Caldas Ferraz, Carlos Javier Orihuela, Thiago Rojas Converso, Michelle Darrieux
This study shows that PspA and the polysaccharide capsule work together to protect Streptococcus pneumoniae from the antimicrobial peptide HNP-1.
bioRxiv · Sep 29, 2025 · PreprintMicrobiology