Carlos Javier Orihuela

This study identifies an alternate protease in S. pneumoniae TIGR4 that rescues ribosomal protein bL27 maturation in the absence of Prp.

The paper shows that biofilm formation during pneumococcal colonization shapes humoral immunity and protection, with the first colonizing strain imprinting immune responses toward biofilm antigens.

This study examines metabolic changes in the lungs during Streptococcus pneumoniae infection, revealing shifts in metabolite levels and bacterial gene expression that correlate with disease progression.

This study shows that PspA and the polysaccharide capsule work together to protect Streptococcus pneumoniae from the antimicrobial peptide HNP-1.

This study shows that the Prp protease cleaves the N-terminal extension of ribosomal protein L27 in S. pneumoniae, and that this cleavage is essential for viability, though the extension itself is not required.

This paper introduces a streamlined method for marker-less allelic replacement in Streptococcus pneumoniae using a single transformation step, reducing complexity and false positives compared to traditional methods.