Hypothalamic CYP46A1 cholesterol metabolism regulates diet-induced obesity
David VC Brito, Adriana Arrulo Pereira, Renata Sandres de Souza Araujo, Bruno Varzea, Xavier Anastacio, Telma Fontão Castro, Célia Alexandra Aveleira, Sara Carmo‐Silva, Marisa Ferreira‐Marques, Ana Luísa De Sousa‐Coelho, José Matos, Leonor Faleiro, Nathalie Cartier, Sandro Alves, Clévio Nóbrega
This study identifies Cyp46a1 as a critical regulator of diet-induced obesity by modulating body weight, adipocyte size, and metabolic parameters through hypothalamic cholesterol metabolism.
bioRxiv · Jan 12, 2026 · PreprintNeuroscience