Author

Clévio Nóbrega

Algarve Biomedical CenterORCID 0000-0002-8312-5292Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2

Frequent Co-Authors

Adriana Arrulo Pereira· 1 shared Ana Luísa De Sousa‐CoelhoiD· 1 shared Ana Rita Fernandes· 1 shared Ana Vasconcelos‐FerreiraiD· 1 shared Bruno Varzea· 1 shared Carlos A. MatosiD· 1 shared Célia Alexandra AveleiraiD· 1 shared Daniela Camargo de OliveiraiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperNeuroscience

Adriana Arrulo Pereira

Mutual co-authors in cluster

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintJan 12, 2026

Hypothalamic CYP46A1 cholesterol metabolism regulates diet-induced obesity

David VC Brito, Adriana Arrulo Pereira, Renata Sandres de Souza Araujo…·Clévio Nóbrega

This study identifies Cyp46a1 as a critical regulator of diet-induced obesity by modulating body weight, adipocyte size, and metabolic parameters through hypothalamic cholesterol metabolism.

DOI 10.64898/2026.01.10.698773

mouseexperimental assay

NeurosciencebioRxivPreprintFeb 14, 2025

Gene Editing for ATXN3 Inactivation in Machado-Joseph disease: CRISPR-Cas9 as a Therapeutic Alternative to TALEN-Induced Toxicity

Sara Monteiro Lopes, Miguel Monteiro Lopes, Daniela Camargo de Oliveira…·Luís Pereira de Almeida

This study compares CRISPR-Cas9 and TALEN gene editing in a mouse model of Machado-Joseph disease, showing CRISPR-Cas9 reduces ATXN3 aggregates and delays disease progression.

DOI 10.1101/2025.02.14.637261

mouseexperimental assay