Célia Alexandra Aveleira

Nuclear aging in polyglutamine-induced neurodegeneration

This study investigates the role of aging in Machado-Joseph disease by analyzing age-related markers in human and animal models, finding decreased lamins and ZMPSTE24 levels and nuclear abnormalities.

Hypothalamic CYP46A1 cholesterol metabolism regulates diet-induced obesity

This study identifies Cyp46a1 as a critical regulator of diet-induced obesity by modulating body weight, adipocyte size, and metabolic parameters through hypothalamic cholesterol metabolism.

Lonafarnib Partially Reverses Cardiac Senescence in Human and Mouse Progeria Models via Autophagy Activation

This study identifies lonafarnib as a potential therapy for progeria-related cardiac senescence by activating autophagy and reducing progerin expression in human and mouse models.

Extracellular matrix mechanical cues (dys)regulate metabolic redox homeostasis due to impaired autophagic flux

This study shows that soft extracellular matrix reduces autophagic flux and disrupts redox balance in neuronal cells, mimicking neurodegenerative disease features.