Disrupting Myeloid Persistence and Replenishment Enables Sustained Control of Esophageal Squamous Cell Carcinoma
Bryan Chee-chad Lung, Alvin Ka-Kiu Leung, Songran Liu, Carissa Wing-Yan Wong, Tsz Hong Lai, Yhi Wong, Cheryl Chee Heng Lung, Anthony W.I. Lo, Ngar‐Woon Kam, Josephine Mun Yee Ko, Wei Dai, Dora Lai‐Wan Kwong, Simon Law, Pablo Scodeller, Maria Li Lung, Valen Zhuoyou Yu
The paper shows that combining CSF1R inhibition with low-dose decitabine suppresses both myeloid persistence and replenishment, leading to sustained control of ESCC in multiple models.
bioRxiv · Aug 28, 2026 · PreprintCancer Biology