Author

Brynelle Myers

Centre for Human Genetics

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Assay:multiome· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Approach:Bayesian inference· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:dimensionality reduction· 1 Approach:experimental assay· 1

Frequent Co-Authors

Ana CvejiciD· 1 shared Andrea TangherloniiD· 1 shared Anjali Gupta HinchiD· 1 shared Anna Maria RanzoniiD· 1 shared Elizabeth Hook· 1 shared Emily MitchelliD· 1 shared Emmanuelle BitouniD· 1 shared Francesca Meteora BuffaiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperGenomics

Ana CvejicORCID

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3 papers

Recent·Most cited

Mammalian spermatogenesis at single-cell resolution downstream of genetic perturbations in meiotic double-strand break repair

Ipsita Agarwal, Brynelle Myers, Martin Houlard, Anjali Gupta Hinch, Emmanuelle Bitoun, Simon Robert Myers

Single-nucleus RNA+ATAC profiling of 32 mice shows asymmetric PRDM9 binding drives asynapsis, pachytene cell loss, aneuploidy and multi-megabase crossover redistribution, tuned by a chromosome 15 locus.

bioRxiv · Sep 11, 2026 · PreprintGenetics✦ In-depth digest

GENESIS: Generating scRNA-Seq data from Multiome Gene Expression

Simone G. Riva, Brynelle Myers, Francesca Meteora Buffa, Andrea Tangherloni

GENESIS converts Multiome GEX data into synthetic scRNA-Seq profiles using generative models, improving cell-type classification accuracy.

IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB) · Aug 20, 2025Peer-reviewedBioinformatics

Lineage tracing of human embryonic development and foetal haematopoiesis through somatic mutations

Michael Spencer Chapman, Anna Maria Ranzoni, Brynelle Myers, Nick Williams, Tim H. H. Coorens, Emily Mitchell, Timothy M. Butler, Kevin J. Dawson, Yvette E. Hooks, Luiza Moore, Jyoti Nangalia, Philip S. Robinson, Elizabeth Hook, Peter J. Campbell, Ana Cvejic

This study uses whole-genome sequencing of single-cell haematopoietic colonies to trace lineage and divergence of embryonic and extra-embryonic tissues in human fetal development.

bioRxiv · May 29, 2020 · PreprintGenomics