Author

Kevin J. Dawson

Wellcome Sanger Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Genomics· 5

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Approach:statistical model· 5 Organism:human· 4 Assay:whole-genome sequencing· 4 Research Focus:differential expression· 2 Research Focus:variant calling· 2 Research Focus:clustering· 1 Organism:mouse· 1 Research Focus:phylogenetics / evolution· 1

Frequent Co-Authors

Peter J. CampbelliD· 5 shared Alex CaganiD· 3 shared Emily MitchelliD· 3 shared Iñigo MartincorenaiD· 3 shared Jyoti NangaliaiD· 3 shared Michael R. StrattoniD· 3 shared Tim H. H. CoorensiD· 3 shared Daniel A. LeongamornlertiD· 2 shared

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2017-2025 · peak 2/yr

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10 top collaborators · 44 mutual co-author links

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Peter J. CampbellORCID

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5 papers

Recent·Most cited

Clonal dynamics and somatic evolution of haematopoiesis in mouse

Chiraag Deepak Kapadia, Nicholas Williams, Kevin J. Dawson, Caroline J. Watson, Matthew J. Yousefzadeh, Duy Tri Le, Kudzai Nyamondo, Sreeya Kodavali, Alex Cagan, Sarah M. Waldvogel, Xiaoyan Zhang, Josephine De La Fuente, Daniel A. Leongamornlert, Emily Mitchell, Marcus Alexander Florez, , Jyoti Nangalia

This study examines clonal dynamics and somatic evolution in mouse haematopoiesis, finding that stem cells accrue mutations at a rate similar to human progenitors and exhibit distinct age-related patterns.

Nature · Mar 5, 2025Peer-reviewedGenomics

The mutational landscape of human somatic and germline cells

Luiza Moore, Alex Cagan, Tim H. H. Coorens, Matthew D. C. Neville, Rashesh Sanghvi, Mathijs Arnoud Sanders, Thomas R. W. Oliver, Daniel A. Leongamornlert, Peter Ellis, Ayesha Noorani, Thomas J. Mitchell, Timothy M. Butler, Yvette E. Hooks, Anne Yvonne Warren, Mette Jørgensen, , Raheleh Rahbari

This study compares mutational landscapes in somatic and germline cells across 29 anatomical structures, identifying key mutational signatures and their contributions to different cell types.

Yearbook of pediatric endocrinology · Sep 12, 2022Peer-reviewedGenomics

Clonal dynamics of haematopoiesis across the human lifespan

Emily Mitchell, Michael Spencer Chapman, Nicholas Williams, Kevin J. Dawson, Nicole Mende, Emily F. Calderbank, Hyunchul Jung, Thomas J. Mitchell, Tim H. H. Coorens, David H. Spencer, Heather E. Machado, Henry Lee-Six, Megan Davies, Daniel Hayler, Margarete A. Fabre, , Peter J. Campbell

This study tracks clonal dynamics in human haematopoiesis across age, finding that clonal diversity sharply declines after 70, driven by positive selection on many genes and loss of Y chromosome in males.

Nature · Jun 1, 2022Peer-reviewedGenomics

Lineage tracing of human embryonic development and foetal haematopoiesis through somatic mutations

Michael Spencer Chapman, Anna Maria Ranzoni, Brynelle Myers, Nick Williams, Tim H. H. Coorens, Emily Mitchell, Timothy M. Butler, Kevin J. Dawson, Yvette E. Hooks, Luiza Moore, Jyoti Nangalia, Philip S. Robinson, Elizabeth Hook, Peter J. Campbell, Ana Cvejic

This study uses whole-genome sequencing of single-cell haematopoietic colonies to trace lineage and divergence of embryonic and extra-embryonic tissues in human fetal development.

bioRxiv · May 29, 2020 · PreprintGenomics

Universal Patterns Of Selection In Cancer And Somatic Tissues

Iñigo Martincorena, Keiran M. Raine, Moritz Gerstung, Kevin J. Dawson, Kerstin Haase, Peter Van Loo, Helen Ruth Davies, Michael R. Stratton, Peter J. Campbell

The paper quantifies selection patterns in cancer evolution using evolutionary genomics methods across 7,664 human cancers, finding positive selection dominates and many driver mutations occur in unknown genes.

Cell · Oct 19, 2017Peer-reviewedGenomics