Emmanuelle Bitoun

Single-nucleus RNA+ATAC profiling of 32 mice shows asymmetric PRDM9 binding drives asynapsis, pachytene cell loss, aneuploidy and multi-megabase crossover redistribution, tuned by a chromosome 15 locus.

The paper identifies ZCWPW1 as a protein recruited by PRDM9 to recombination hotspots and shows it is essential for meiotic double strand break repair and fertility in mice.

The paper maps non-crossover events in meiotic recombination, showing how genetic diversity affects repair mechanisms and contributes to hybrid infertility.

The paper investigates PRDM9 binding and its effects on meiotic recombination and gene expression in human cells, finding that DNA-binding motifs and histone modifications predict recombination outcomes.