Simon Robert Myers

Single-nucleus RNA+ATAC profiling of 32 mice shows asymmetric PRDM9 binding drives asynapsis, pachytene cell loss, aneuploidy and multi-megabase crossover redistribution, tuned by a chromosome 15 locus.

This study uses joint genealogies of dogs, wolves, and coyotes to uncover evolutionary forces shaping the dog genome, identifying mutation-rate pulses, selection signatures, and introgression events.

This paper introduces GhostBuster, a method to detect unsampled admixture events in human history using genome-wide genealogies, revealing multiple back-to-Africa migrations and deep ancestral lineages.

The paper identifies genetic interactions affecting quantitative traits in the UK Biobank by testing SNP interactions with polygenic scores, finding 144 independent interactions across 52 traits.

This paper builds a haplotype reference panel from Genomics England data and imputes UK Biobank data, revealing more rare variants and suggesting limitations in detecting rare variant associations with current sample sizes.

The paper shows genetic effect sizes are similar across African and European populations for most traits, suggesting shared causal mutations and improving GWAS portability.

The paper estimates the fitness costs of loss-of-function mutations in humans and relates them to disease severity and study design.

This paper introduces methods to infer population histories using ancient genomes and genealogies, revealing insights into population dynamics and mutation rates in ancient populations.

The paper identifies ZCWPW1 as a protein recruited by PRDM9 to recombination hotspots and shows it is essential for meiotic double strand break repair and fertility in mice.

The paper analyzes the genetic structure of modern-day Italians to reveal ancient and archaic ancestries shaping Southern European populations and Neanderthal DNA distribution.

This paper introduces a method to estimate genome-wide genealogies for thousands of samples, revealing new insights into human evolutionary history and selection.

The paper maps non-crossover events in meiotic recombination, showing how genetic diversity affects repair mechanisms and contributes to hybrid infertility.

The paper develops a framework to analyze single-cell transcriptomes from mouse testes, identifying gene regulatory programs and pathological processes in mutant strains.

This paper introduces an algorithm to infer ancestry segments and admixture events without prior knowledge of mixing groups, showing improved accuracy over existing methods.

The paper analyzes genome-wide data from Spanish individuals to reveal fine-scale genetic structure and historical population movements, including North African ancestry from the Muslim period.

The paper investigates PRDM9 binding and its effects on meiotic recombination and gene expression in human cells, finding that DNA-binding motifs and histone modifications predict recombination outcomes.

The paper identifies and analyzes non-crossover gene conversion events in humans, finding strong GC bias and unexpected clustering of conversion tracts.