A Site-Specific Organometallic Approach for Installing Tyrosine Phosphorylation Mimics to Decipher the Role of Phosphorylation in Alpha-Synuclein (aSyn) Aggregation and Seeding
Shaswati Mandal, Xiaoxi Lin, Anastasia V. Gemelli, Manjeet Singh, Anne‐Laure Mahul‐Mellier, Yllza Jasiqi, Buchra Bouri, Muhammad Jbara, Hilal Ahmed Lashuel
This paper introduces a site-specific organometallic method to install tyrosine phosphorylation mimics in alpha-synuclein, revealing that di- and tri-phosphorylation slow aggregation and reduce seeding activity.
bioRxiv · Dec 8, 2025 · PreprintBiochemistry