BiochemistrybioRxivPreprint
A Site-Specific Organometallic Approach for Installing Tyrosine Phosphorylation Mimics to Decipher the Role of Phosphorylation in Alpha-Synuclein (aSyn) Aggregation and Seeding
Shaswati Mandal, Xiaoxi Lin, Anastasia V. Gemelli…·Hilal Ahmed Lashuel
This paper introduces a site-specific organometallic method to install tyrosine phosphorylation mimics in alpha-synuclein, revealing that di- and tri-phosphorylation slow aggregation and reduce seeding activity.
DOI 10.64898/2025.12.05.692498