An N, S-acetylated L-cysteine-cysteamine conjugate hinders pyocyanin redox cycling to weaken Pseudomonas aeruginosa biofilm and dampens LPS-driven acute pulmonary inflammation
Michela Bruschi, Sofia Masini, Francesco Palma, Y Xiaoqiu, Cássia Lisboa Braga, Matteo Gregori, C Bucci, Francesca Bartoccini, Michele Menotta, Elisabetta Manuali, Lucia Minelli, Daniela Ligi, Ferdinando Mannello, Francesca Monittola, Carolina Zara, , Alessandra Fraternale
This paper identifies I-152 as a compound that disrupts Pseudomonas aeruginosa biofilm formation and reduces LPS-induced inflammation through redox cycling inhibition and anti-inflammatory effects.
bioRxiv · May 29, 2026 · PreprintPharmacology & Toxicology