The pseudoproteinase iRhom2 critically promotes acute lung inflammation
Christine Lux, Selcan Kahveci-Türköz, Katharina Schun, Aaron Babendreyer, C Martin, Petr Kašpárek, Radislav Sedláček, Stefan Düsterhöft, Andreas Ludwig
This study shows that iRhom2 deficiency reduces acute lung inflammation in mice by impairing ADAM17-mediated shedding of inflammatory mediators and neutrophil recruitment.
bioRxiv · Jun 9, 2026 · PreprintPharmacology & Toxicology