Stefan Düsterhöft

This study identifies TMEM115 as a two-factor component with Rab6A that recruits the golgin TMF1 to the Golgi apparatus, with implications for protein trafficking and disease.

The paper identifies naturally occurring ACE2 stalk variants that differentially affect soluble ACE2 release and surface expression of B0AT1.

This study shows that iRhom2 deficiency reduces acute lung inflammation in mice by impairing ADAM17-mediated shedding of inflammatory mediators and neutrophil recruitment.

This study shows that the JAK2 V617F mutation enhances IL-6 sensitivity by promoting gp130 dimerization and expression in myeloid cells, contributing to chronic inflammation in MPN.

This study identifies a phosphorylation-independent 14-3-3 interaction site in iRhom2's N-terminus that regulates ADAM17 activity and shows how mutations in this region cause different pathological outcomes.

The paper shows that ADAM17-triggered TNF signaling in Drosophila retina protects against age-related lipid droplet-mediated degeneration by initially buffering ROS but later causing toxic lipid release.