Intracellular Passage Of Na+ In An Active State G Protein Coupled Receptor
o. N. Vickery, C. A. Carvalheda, S. A. Zaidi, A. V. Pisliakov, V. Katritch, U. Zachariae
This study shows that Na+ ion movement from an extracellular binding site to the cytosol is a key step in GPCR activation, stabilizing active-state conformations.
bioRxiv · Jul 21, 2017Biophysics