CD4 and CD8 co-receptors modulate functional avidity of CD1b-restricted T cells.
C. A. James, Y. Xu, M. S. Aguilar, L. Jing, E. D. Layton, M. Gilleron, A. J. Minnaard, T. Scriba, C. L. Day, E. H. Warren, D. M. Koelle, C. Seshadri
This study investigates how CD4 and CD8 co-receptors affect the functional avidity and activation of CD1b-restricted T cells specific for mycobacterial lipid antigens, revealing distinct functional profiles and proliferation patterns.
bioRxiv · Oct 17, 2020Immunology