Author

C. A. Tye

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

B. Kalfaoglu· 2 shared J. Almeida-Santos· 2 shared M. Ono· 2 shared J. Hassan· 1 shared M. E. Selkirk· 1 shared R. Berkachy· 1 shared Y. Satou· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 18 mutual co-author links

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2 shared papersImmunology

B. Kalfaoglu

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2 papers

Recent·Most cited

Temporal profiling of CD4 T-cell activation and differentiation upon SARS-CoV-2 spike protein immunisation

J. Almeida-Santos, R. Berkachy, C. A. Tye, J. Hassan, B. Kalfaoglu, M. E. Selkirk, M. Ono

This study investigates how TCR signaling controls CD4 T-cell differentiation and Treg development after SARS-CoV-2 spike protein immunization using temporal profiling techniques.

bioRxiv · Jul 21, 2022 · PreprintImmunology

T-cell hyperactivation and paralysis in severe COVID-19 infection revealed by single-cell analysis

B. Kalfaoglu, J. Almeida-Santos, C. A. Tye, Y. Satou, M. Ono

This study identifies hyperactivation and paralysis of CD4+ T-cells in severe COVID-19 through single-cell analysis, revealing their role in cytokine release syndrome and viral entry.

bioRxiv · May 26, 2020Immunology