Y. Satou

A heterocyclic compound inhibits viral release by inducing cell surface BST2/Tetherin/CD317/HM1.24

This paper identifies a heterocyclic compound, HT-7, that inhibits HIV-1 release by increasing cell surface BST2 expression with minimal cellular toxicity.

Viral antigen mismatch affects antiviral T-cell response and may impair immunotherapeutic efficacy against ATL

This study shows that mismatch between viral antigen epitopes and T-cell responses in HTLV-1 infection may reduce immunotherapy effectiveness against ATL.

HIV-Tocky system to visualize proviral expression dynamics

The paper introduces HIV-Tocky, a reporter system using a fluorescent Timer protein to visualize HIV-1 provirus expression dynamics and identifies two latent subsets of proviruses.

Single-cell level temporal profiling of tumour-reactive T cells under immune checkpoint blockade

This study uses a novel mouse model to analyze how checkpoint blockade affects tumour-reactive T cell activation dynamics at the single-cell level.

Lymphoma cells are circulating in blood of Enzootic Bovine Leukosis and clonality value of virus-infected cells is a useful information for the diagnostic test

The paper demonstrates that clonality values of BLV-infected cells in blood can reliably detect Enzootic Bovine Leukosis and are useful for diagnostic testing.

A widely-distributed HIV-1 provirus elimination assay to evaluate latency-reversing agents in vitro

The paper develops a new assay to evaluate latency-reversing agents by eliminating HIV-1 proviruses in a long-term cell culture system.

Retrovirus-induced leukemia - hijack of T-cell activation mechanisms revealed by single-cell analysis

This study uses single-cell RNA-Seq and TCR-Seq to show HTLV-1-infected T-cells transition into highly activated ATL cells with Treg signatures and upregulated HLA class II, enabling immune evasion.

Movements of ancient human endogenous retroviruses detected in SOX2-expressing cells

The paper shows SOX2 regulates HERV-K transcription and retrotransposition in stem cells, suggesting a role in embryonic protection while limiting genomic harm.

T-cell hyperactivation and paralysis in severe COVID-19 infection revealed by single-cell analysis

This study identifies hyperactivation and paralysis of CD4+ T-cells in severe COVID-19 through single-cell analysis, revealing their role in cytokine release syndrome and viral entry.