Author

J. Almeida-Santos

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2

Frequent Co-Authors

B. Kalfaoglu· 3 shared M. Ono· 3 shared C. A. Tye· 2 shared I. A. Cabral· 2 shared J. Demengeot· 2 shared J. Hassan· 2 shared M.-L. Bergman· 2 shared Y. Satou· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersImmunology

B. Kalfaoglu

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Author profile →

5 papers

Recent·Most cited

Temporal profiling of CD4 T-cell activation and differentiation upon SARS-CoV-2 spike protein immunisation

J. Almeida-Santos, R. Berkachy, C. A. Tye, J. Hassan, B. Kalfaoglu, M. E. Selkirk, M. Ono

This study investigates how TCR signaling controls CD4 T-cell differentiation and Treg development after SARS-CoV-2 spike protein immunization using temporal profiling techniques.

bioRxiv · Jul 21, 2022 · PreprintImmunology

Single-cell level temporal profiling of tumour-reactive T cells under immune checkpoint blockade

J. Hassan, E. Appleton, B. Kalfaoglu, M. Pedersen, J. Almeida-Santos, H. Kanemaru, N. Irie, S. Foo, O. Reda, B. J. Y. Tan, I.-m. Okazaki, T. Okazaki, Y. Satou, K. Harrington, A. Melcher, M. Ono

This study uses a novel mouse model to analyze how checkpoint blockade affects tumour-reactive T cell activation dynamics at the single-cell level.

bioRxiv · Jul 19, 2022 · PreprintImmunology

T-cell hyperactivation and paralysis in severe COVID-19 infection revealed by single-cell analysis

B. Kalfaoglu, J. Almeida-Santos, C. A. Tye, Y. Satou, M. Ono

This study identifies hyperactivation and paralysis of CD4+ T-cells in severe COVID-19 through single-cell analysis, revealing their role in cytokine release syndrome and viral entry.

bioRxiv · May 26, 2020Immunology

Interruption of thymic activity in adults improves responses to tumor immunotherapy

J. Almeida-Santos, M.-L. Bergman, I. A. Cabral, J. Demengeot

This study shows that interrupting thymic activity in adult mice reduces Treg cells and enhances tumor immunotherapy responses.

bioRxiv · Jan 8, 2020Immunology

A weak Foxp3 hypomorph enhances spontaneous and therapeutic immune surveillance of cancer in mice

J. Almeida-Santos, M.-L. Bergman, I. A. Cabral, V. Correia, I. Caramalho, J. Demengeot

This study shows that a weak Foxp3 hypomorph allele enhances anti-tumor immunity in mice, reducing tumor growth and improving response to immunotherapy.

bioRxiv · Mar 7, 2019Cancer Biology