Toxoplasma ceramide synthases: a curious case of gene duplication, divergence and key functionality
Z. Koutsogiannis, J. Mina, C. Albus, M. Kol, J. Holthuis, E. Pohl, P. Denny
This paper identifies and analyzes ceramide synthases in Toxoplasma gondii, showing TgCerS1 is functional while TgCerS2 is catalytically inactive but more critical for parasite fitness.
bioRxiv · Jan 5, 2022 · PreprintMicrobiology