Potassium-chelating drug sodium polystyrene sulfonate enhances lysosomal function and suppresses proteotoxicity
C. Arputhasamy, M. Lucanic, A. Rane, M. Schmidt, T. Garett, A. C. Foulger, M. Broussalian, E. Battistoni, R. B. Brem, G. J. Lithgow, M. Chamoli, J. K. Andersen
This study shows that the FDA-approved drug sodium polystyrene sulfonate enhances lysosomal function and reduces proteotoxicity in C. elegans and human neuronal cells, while also increasing lifespan.
bioRxiv · Oct 21, 2021Cell Biology