Author

R. B. Brem

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 7 Cell Biology· 1 Genomics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:yeast· 6 Research Focus:chromatin & epigenetic regulation· 5 Research Focus:gene regulatory network inference· 5 Approach:statistical model· 4 Research Focus:cell type annotation· 3 Assay:DNA methylation· 3 Assay:bulk RNA-seq· 2

Frequent Co-Authors

M. B. Abrams· 4 shared F. AlZaben· 3 shared C. A. Dubin· 2 shared D. M. Bautista· 2 shared J. M. Skerker· 2 shared J. N. Chuong· 2 shared A. A. Caudy· 1 shared A. C. Foulger· 1 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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4 shared papersEvolutionary Biology

M. B. Abrams

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Author profile →

10 papers

Recent·Most cited

Signatures of innovation and selection in the extremotolerant yeast Kluyveromyces marxianus

K. E. Christensen, A. Deal, J. T. J. Wang, A. Duarte, J. L. Edwards, Z. Ma, J. L. N. Goodman, S. I. Padilla, E. Szewczyk, C. Rha, R. B. Brem

This study identifies molecular and genetic features underlying stress resistance in the extremotolerant yeast Kluyveromyces marxianus through omic profiling and evolutionary analysis.

bioRxiv · Dec 21, 2023Evolutionary Biology

Stem cell transcriptional profiles from mouse subspecies reveal cis-regulatory evolution at translation genes

N. M. Simon, Y. Kim, D. M. Bautista, J. R. Dutton, R. B. Brem

The paper identifies cis-regulatory evolution in translation genes in stem cells of M. m. castaneus compared to sister taxa using expression and population-genomic data.

bioRxiv · Jul 18, 2023 · PreprintEvolutionary Biology

Temperature-dependent genetics of thermotolerance between yeast species

M. B. Abrams, R. B. Brem

The paper investigates how thermotolerance in yeast species evolved by analyzing genetic differences between Saccharomyces cerevisiae and S. paradoxus.

bioRxiv · Jan 11, 2022 · PreprintEvolutionary Biology

Potassium-chelating drug sodium polystyrene sulfonate enhances lysosomal function and suppresses proteotoxicity

C. Arputhasamy, M. Lucanic, A. Rane, M. Schmidt, T. Garett, A. C. Foulger, M. Broussalian, E. Battistoni, R. B. Brem, G. J. Lithgow, M. Chamoli, J. K. Andersen

This study shows that the FDA-approved drug sodium polystyrene sulfonate enhances lysosomal function and reduces proteotoxicity in C. elegans and human neuronal cells, while also increasing lifespan.

bioRxiv · Oct 21, 2021Cell Biology

Joint effects of genes underlying a temperature specialization tradeoff in yeast

F. AlZaben, J. N. Chuong, M. B. Abrams, R. B. Brem

The paper investigates how eight unlinked thermotolerance genes in yeast work together when transferred to a thermosensitive species, showing their combined beneficial effects and a tradeoff in cold tolerance.

PLOS Genetics · Sep 14, 2021Peer-reviewedEvolutionary Biology

Barcoded reciprocal hemizygosity analysis via sequencing illuminates the complex genetic basis of yeast thermotolerance

M. B. Abrams, J. N. Chuong, F. AlZaben, C. A. Dubin, J. M. Skerker, R. B. Brem

The paper improves RH-seq by adding barcodes for efficient sequencing, then uses it to identify thermotolerance-related loci in yeast species divergence.

bioRxiv · Jul 26, 2021Evolutionary Biology

Cold survival and its molecular mechanisms in a locally adapted nematode population

W. Wang, A. G. Flury, J. L. Garrison, R. B. Brem

The paper identifies cold resistance in a nematode population and finds genetic and transcriptional differences between temperate and tropical strains.

bioRxiv · May 10, 2021Evolutionary Biology

Molecular and evolutionary mechanisms of yeast thermotolerance

M. B. Abrams, C. A. Dubin, F. AlZaben, J. Bravo, P. M. Joubert, C. V. Weiss, R. B. Brem

The paper investigates the molecular and evolutionary mechanisms underlying thermotolerance in yeast, identifying positive selection at the ESP1 gene and its functional impact on growth at high temperatures.

bioRxiv · Aug 31, 2020Evolutionary Biology

Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis

C. M. Walsh, R. Z. Hill, J. Schwendinger-Schreck, J. Deguine, E. C. Brock, N. Kucirek, Z. Rifi, J. Wei, K. Gronert, R. B. Brem, G. M. Barton, D. M. Bautista

This study identifies neutrophils as key initiators of itch in atopic dermatitis and shows that CXCR3 antagonism reduces chronic itch.

bioRxiv · Sep 24, 2019Immunology

Transposon insertional mutagenesis in Saccharomyces uvarum reveals trans-acting effects influencing species dependent essential genes

M. R. Sanchez, C. Payen, F. Cheong, B. T. Hovde, S. Bissonnette, A. P. Arkin, J. M. Skerker, R. B. Brem, A. A. Caudy, M. J. Dunham

This study uses transposon mutagenesis in Saccharomyces uvarum to identify species-dependent essential genes and shows that trans-acting factors influence gene essentiality despite cross-species complementation.

Genome Research · Mar 1, 2019Peer-reviewedGenomics