Mucosal Immunization of Cynomolgus Macaques with Adenoviral Vector Vaccine Elicits Neutralizing Nasal and Serum Antibody to Several SARS-CoV-2 Variants
B. A. Flitter, C. A. Lester, S. N. Tedjakusuma, E. G. Dora, N. Peinovich, M. Cortese, C. I. Martinez, C. B. Jegede, E. D. Neuhaus, S. N. Tucker
This study evaluates mucosal immunization with SARS-CoV-2 adenoviral vaccines in macaques, finding that a Wuhan-specific vaccine induces strong cross-reactive serum and nasal antibody responses against multiple variants.
bioRxiv · Feb 21, 2022 · PreprintImmunology