MicrobiologybioRxivPreprint
Antifungal activity of fibrate-based compounds and substituted pyrroles inhibiting the enzyme 3-hydroxy-methyl-glutaryl-CoA reductase of Candida glabrata (CgHMGR), and decreasing yeast viability and ergosterol synthesis
L. Villa-Tanaca, D. A. Madrigal-Aguilar, A. Gonzalez-Silva…·J. Tamariz
The paper evaluates fibrate-based and pyrrole-containing compounds as inhibitors of C. glabrata's HMGR enzyme, showing they reduce yeast viability and ergosterol synthesis.
DOI 10.1101/2021.09.14.460412