Antifungal activity of fibrate-based compounds and substituted pyrroles inhibiting the enzyme 3-hydroxy-methyl-glutaryl-CoA reductase of Candida glabrata (CgHMGR), and decreasing yeast viability and ergosterol synthesis
L. Villa-Tanaca, D. A. Madrigal-Aguilar, A. Gonzalez-Silva, B. Rosales-Acosta, C. Bautista-Crescencio, J. Ortiz-Alvarez, J. Sanchez-Navarrete, C. Escalante, C. Hernandez-Rodriguez, G. Chamorro-Cevallos, J. Tamariz
The paper evaluates fibrate-based and pyrrole-containing compounds as inhibitors of C. glabrata's HMGR enzyme, showing they reduce yeast viability and ergosterol synthesis.
bioRxiv · Sep 14, 2021 · PreprintMicrobiology